Diagnostic antibodies and antigens for Epilepsy-related valproate (VPA) toxicity testing: Sodium valproate (VPA)

Valproate is a commonly used antiepileptic drug for the treatment of epilepsy and seizures. It is safe for use in both adults and children more than three years of age. Valproate toxicity can occur both accidentally and intentionally. Acute valproate overdose usually presents with CNS depression/encephalopathy, electrolyte abnormalities such as hypernatremia, elevated transaminase levels, hyperammonemia, and hepatoxicity. In patients with a severe overdose of valproate, patients can present with hypotension, tachycardia, respiratory depression, metabolic acidosis, cerebral edema, and valproate-related hyperammonemic encephalopathy which may progress to coma and death. GENEMEDI developed the Sodium valproate (VPA) antigens and antibodies for the diagnosis of valproate toxicity based on ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.

Classification: VPA

Sodium valproate (VPA)

Cat No.	Species	Biomarker	Disease	Cat No.of Antigen	Bioactivity validation of Antigen	Cat No.of Antibodies	Bioactivity validation of Antibodies	Order
GMP-SMT-VPA	Human	Sodium valproate (VPA)	toxicity	GMP-SMT-VPA-Ag01: BSA-Sodium valproate (VPA); GMP-SMT-VPA-Ag02: OVA-Sodium valproate (VPA):	Competitive immunoassay-validated hapten-carrier conjugates [BSA-&OVA-Sodium valproate (VPA)], Sodium valproate (VPA) antibodies binding, Immunogen in Competitive immunoassay validation, Elisa, lateral-flow tests,and other immunoassays as control material in VPA level test of Epilepsy (toxicity) and related syndrome evaluation.	GMP-SMT-VPA-Ab01: Anti-Sodium valproate (VPA) mouse monoclonal antibody(mAb)	Human Sodium valproate (VPA) binding, in Competitive immunoassay validation, Elisa, lateral-flow tests, and other immunoassays in VPA level test of Epilepsy (toxicity) and related syndrome evaluation.